Canada: Neurological dysfunction in diabetes presence contributes to impaired renal blood flow and ischemic injury in patients with type 1 diabetes; however, early autonomic dysfunction does not seem to be associated with changes in kidney function, new research shows. The findings appeared in the Journal of Diabetes and its Complications.

The study was conducted by Yuliya Lytvyn, University of Toronto, Toronto, Ontario, Canada, and colleagues to determine the relationship between renal hemodynamic function and neuropathy in type 1 diabetes (T1D) adults with ≥ 50 years compared to nondiabetic controls.
For this purpose, the researchers measured effective renal plasma flow (ERPF,p-aminohippurate), glomerular filtration rate (GFR, inulin), corneal confocal microscopy, modified Toronto Clinical Neuropathy Score (mTCNS), heart rate variability (autonomic function), and nerve conduction; estimation of (RA) and efferent (RE) arteriolar resistances were done in 74 patients with T1D and 75 controls.
eGFRMDRD < 60 ml/min/1.73 m2 or 24-h urine albumin excretion >30 mg/day defined diabetic kidney disease (DKD) non-resistors. The relationships between renal function and neuropathy measures were examined after adjusting for sex, age, systolic blood pressure, HbA1c, 24-h urine albumin to creatinine ratio, and low-density lipoprotein cholesterol.
The study demonstrated the following findings:
“The findings suggest that neurological dysfunction in diabetes presence may be associated with impaired renal blood flow leading to ischemic injury in type 1 diabetes patients,” the researchers wrote in their conclusion. “Early autonomic dysfunction does not seem to contribute to the neurologic dysfunction observed in this cohort of patients.”
Lytvyn Y, Albakr R, Bjornstad P, Lovblom LE, Liu H, Lovshin JA, Boulet G, Farooqi MA, Weisman A, Keenan HA, Brent MH, Paul N, Bril V, Perkins BA, Cherney DZI. Renal hemodynamic dysfunction and neuropathy in longstanding type 1 diabetes: Results from the Canadian study of longevity in type 1 diabetes. J Diabetes Complications. 2022 Sep 28;36(11):108320. doi: 10.1016/j.jdiacomp.2022.108320. Epub ahead of print. PMID: 36201892.
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at Contact no. 011-43720751
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