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NUTRITION
Nature Reviews Endocrinology (2022)
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Non-nutritive sweeteners (NNSs) seem to be a good substitute for sugar; they have the much-desired sweet taste but lack caloric content. A multi-arm randomized controlled trial assessing the effects of four NNSs on human metabolic health and the gut microbiome was recently published in Cell. The results further feed the long-standing debate on whether NNS use is indeed wholesome for human health.
Refers to Suez, J. et al. Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance. Cell https://doi.org/10.1016/j.cell.2022.07.016 (2022)
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M.N. is supported by a personal ZONMW VICI grant 2020 [09150182010020]. H.H. is supported by a Senior Fellowship of the Dutch Diabetes Research Foundation (2019.82.004).
Department of Internal Medicine, Amsterdam University Medical Centers, Location AMC, Amsterdam, Netherlands
Max Nieuwdorp & Hilde Herrema
Department of Experimental Vascular Medicine, Amsterdam University Medical Centers, Location AMC, Amsterdam, Netherlands
Max Nieuwdorp & Hilde Herrema
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Correspondence to Max Nieuwdorp or Hilde Herrema.
M.N. is founder and member of the Scientific Advisory Board of Caelus Pharmaceuticals, the Netherlands, which has no direct relation to the outcomes of this study. H.H. declares no competing interests.
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Nieuwdorp, M., Herrema, H. Non-nutritive sweeteners — too sweet to be wholesome?. Nat Rev Endocrinol (2022). https://doi.org/10.1038/s41574-022-00758-4
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Published: 17 October 2022
DOI: https://doi.org/10.1038/s41574-022-00758-4
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