USA: Several HbA1c metrics positively correspond with coronary artery calcium (CAC) volume and independently predict incident cardiovascular disease (CVD) events in type 1 diabetes, findings from CACTI Study have shown.
“Even after adjustment for numerous CVD risk factors, these associations with CVD events persisted for mean HbA1c, baseline HbA1c, and time-varying HbA1c,” the researchers wrote in their study published in The Journal of Clinical Endocrinology & Metabolism.
Interventions that decrease mean glucose have lowered macro- and microvascular complication rates in type 1 diabetes (T1D). However, there is a difference in CV risk between type 1 diabetes patients and the general population, indicating that factors beyond HbA1c normalization drive cardiovascular outcomes.
Against the above background, William B Horton from the University of Virginia School of Medicine in Charlottesville, VA, and colleagues aimed to determine whether various HbA1c metrics predict anatomic CVD risk factors and events in people with type 1 diabetes.
For this purpose, the researchers used linear regression to analyze the relationship between various HbA1c metrics and anatomic CVD risk factors. Cox regression was used to model their relationship to incident CVD events in the CACTI Study.
The study revealed the following findings:
“We found that several hemoglobin A1C positively correlated with CAC volume and independently predicted CVD events in the CACTI T1D cohort,” the researchers wrote. “These associations with cardiovascular events persisted for mean HbA1c, baseline HbA1c, and time-varying HbA1c even after adjusting for numerous CVD risk factors.”
Reference:
William B Horton, MD, MSc, FACP, Janet K Snell-Bergeon, PhD, MPH, HbA1c Variability Metrics Predict Coronary Artery Calcium and Cardiovascular Events in Type 1 Diabetes: the CACTI Study, The Journal of Clinical Endocrinology & Metabolism, 2023;, dgad019, https://doi.org/10.1210/clinem/dgad019
Medha Baranwal joined Medical Dialogues as an Editor in 2018 for Speciality Medical Dialogues. She covers several medical specialties including Cardiac Sciences, Dentistry, Diabetes and Endo, Diagnostics, ENT, Gastroenterology, Neurosciences, and Radiology. She has completed her Bachelors in Biomedical Sciences from DU and then pursued Masters in Biotechnology from Amity University. She has a working experience of 5 years in the field of medical research writing, scientific writing, content writing, and content management. She can be contacted at editorial@medicaldialogues.in. Contact no. 011-43720751
Editorial
Journal Club Today
Health News Today