OrsoBio Acquires Phase 2-Ready, Selective ACC2 Inhibitor from Shionogi & Co., Ltd. for the Treatment of Type 2 Diabetes – BioSpace

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Published: Nov 02, 2022
— Company announces positive Phase 1 clinical data of TLC-3595 to be presented at The Liver Meeting® 2022 —
PALO ALTO, Calif.–(BUSINESS WIRE)– OrsoBio, Inc., a clinical-stage biopharmaceutical company developing treatments for severe metabolic disorders, today announced it has acquired exclusive worldwide rights to an ACC2 inhibitor program from Shionogi & Co., Ltd. The intellectual property includes lead candidate TLC-3595 (formerly S-723595), a novel and selective ACC2 inhibitor designed to treat type 2 diabetes by increasing fatty acid oxidation (FAO), reducing ectopic lipid accumulation, and improving insulin sensitivity in skeletal muscle and liver. TLC-3595 also has potential for treating other conditions characterized by impaired FAO, including cirrhosis with sarcopenia and genetic, long-chain FAO disorders.
“Increasing fatty acid oxidation via selective ACC2 inhibition without adverse effects of ACC1 inhibition, such as hypertriglyceridemia and thrombocytopenia, offers great promise for improving insulin sensitivity in patients with type 2 diabetes,” said Rob Myers, MD, Chief Medical Officer of OrsoBio. “Our first-in-human study of TLC-3595 and preclinical data showing reduced lipid accumulation in muscle and liver and improved insulin sensitivity, support our plans to initiate a Phase 2a trial in subjects with insulin resistance in the first half of 2023.”
OrsoBio will present data from a Phase 1 trial of TLC-3595 in a poster (Abstract #3677) entitled “Evaluation of the safety and pharmacokinetic effects of the oral, acetyl-CoA carboxylase-2 (ACC2) inhibitor TLC-3595 in healthy volunteers” at AASLD’s The Liver Meeting®, November 4-8, 2022, in Washington, D.C. In this Phase 1 single and multiple ascending dose trial, TLC-3595 treatment for up to 14 days was well tolerated, all adverse events were mild, and no serious adverse events were observed. TLC-3595 treatment led to improvements in LDL and total cholesterol, confirming the compound’s pharmacodynamic effects, and its pharmacokinetics support once daily oral administration.
“Insulin resistance is the major predisposing factor in the pathogenesis of type 2 diabetes. Previous studies by my group have demonstrated that ACC2 knockout mice manifest increased energy expenditure and improved insulin sensitivity, which is mediated by increased fatty acid oxidation leading to reductions in ectopic lipid content in liver and skeletal muscle. These results strongly support the development of novel pharmacologic ACC2 inhibitors for the treatment of type 2 diabetes,” said Gerald Shulman, MD, PhD, MACP, MACE, FRCP, the George R. Cowgill Professor of Medicine and Professor of Cellular and Molecular Physiology at Yale School of Medicine, Co-Director of the Yale Diabetes Research Center, and scientific advisor to OrsoBio. “Based on its potency and selectivity, and preclinical data to date, I see great potential for TLC-3595 to improve insulin sensitivity in patients with type 2 diabetes, and this mechanism to complement approved therapies.”
About TLC-3595 and ACC2 Inhibition
ACC2 regulates the oxidation of fatty acids by controlling their entry into mitochondria. In ACC2 knockout mice, and in preclinical models with TLC-3595 treatment, increased fatty acid oxidation (FAO) and reduced lipid accumulation in skeletal muscle, liver, and heart, and improved insulin sensitivity have been observed. Selectively inhibiting ACC2 with TLC-3595 offers promise as a therapy for type 2 diabetes and other disorders characterized by impaired FAO.
About OrsoBio, Inc.
OrsoBio, Inc. is a privately held, clinical-stage biopharmaceutical company dedicated to developing therapies to treat severe metabolic disorders, including type 2 diabetes, severe dyslipidemias, lipodystrophies, and nonalcoholic steatohepatitis. The company was co-founded by Mani Subramanian, MD, PhD, former Therapeutic Area Head for Liver Diseases at Gilead Sciences, and Samsara BioCapital. OrsoBio currently has four programs in clinical and preclinical development with first-in-class compounds that address central pathways in energy metabolism. For more information, please visit www.orsobio.com.
About Shionogi
Shionogi & Co., Ltd. is a leading global research-driven pharmaceutical company based in Japan dedicated to bringing benefits to patients based on its corporate philosophy of “supplying the best possible medicine to protect the health and wellbeing of the patients we serve.” Our pipeline is focused on infectious disease, pain, CNS, and new growth areas as society’s needs demand. For more information on Shionogi & Co., Ltd., visit https://www.shionogi.com/global/en/.
About Samsara BioCapital
Samsara BioCapital is a new breed of biotech investment fund focused on translating cutting-edge biology into new therapies to treat patients with unmet medical needs. Founded in 2016 by Srinivas Akkaraju, MD, PhD, our team of scientists, investors and entrepreneurs takes a long-term view to value creation across all stages of public and private life science companies. We believe in a collaborative, hands-on approach, working closely with entrepreneurs to harness exciting scientific advances and build leading companies. Samsara actively manages assets on behalf of endowments, foundations, and family offices. For more information, please visit www.samsaracap.com.

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Gwen Gordon
858-245-5684
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Source: OrsoBio, Inc.
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