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Nature Metabolism (2023)
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Human pluripotent stem cell-derived pancreatic islets (PSC-islets) hold promise in type I diabetes treatment, although their delivery is a challenge. We describe a new abdominal infusion transplantation protocol that enables the survival, maturation and maintenance of functional PSC-islets in diabetic monkeys.
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Du, Y. et al. Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates. Nat. Med. 28, 272–282 (2022). This paper reports the generation of pancreatic islet tissues from human PSCs.
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Shapiro, A. M. J. et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med. 343, 230–238 (2000). This paper reports the Edmonton protocol for islet transplantation through the portal vein.
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Shapiro, A. M. J., Pokrywczynska, M. & Ricordi, C. Clinical pancreatic islet transplantation. Nat. Rev. Endocrinol. 13, 268–277 (2017). This review article presents an overview and the challenges of clinical islet transplantation.
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Guan, J. et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature 605, 325–331 (2022). This paper reports the chemical induction of CiPSCs by chemical reprogramming.
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Liu, H. et al. Generation of Induced Pluripotent Stem Cells from Adult Rhesus Monkey Fibroblasts. Cell Stem Cell 3, 587–590 (2008). This paper reports the generation of monkey induced PSCs.
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Shi, Y. et al. Inducing embryonic stem cells to differentiate into pancreatic β cells by a novel three-step approach with activin A and all-trans retinoic acid. Stem Cells 23, 656–662 (2005). This paper reports the generation of insulin-producing cells from mouse embryonic stem cells.
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This is a summary of: Liang, Z. et al. Implantation underneath the abdominal anterior rectus sheath enables effective and functional engraftment of stem-cell-derived islets. Nat. Metab. https://doi.org/10.1038/s42255-022-00713-7 (2023).
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Abdominal transplantation of pancreatic islets to protect against type 1 diabetes. Nat Metab (2023). https://doi.org/10.1038/s42255-022-00714-6
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Published: 09 January 2023
DOI: https://doi.org/10.1038/s42255-022-00714-6
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