Diabetes Self-Management
Diabetes Self-Management
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January 4, 2023
Jardiance (empagliflozin) has been shown to reduce blood glucose levels in children and adolescents with type 2 diabetes, according to an announcement from the drug’s manufacturer, Boehringer Ingelheim, on the results of a clinical trial.
Jardiance belongs to a group of type 2 diabetes drugs called SGLT2 inhibitors, which work by making your kidneys remove glucose from your blood and excrete it in your urine. These drugs have grown in popularity since their introduction in the United States about a decade ago, although they may not always be prescribed to the people who stand to benefit the most from them. Recently published research shows that these drugs may reduce the risk for severe COVID-19 in people who take them, and previous studies have shown that other health benefits may include heart protection and a lower risk for serious kidney problems.
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For the latest study, 158 participants ages 10 to 17 with type 2 diabetes were randomly assigned to take either Jardiance, Tradjenta (linagliptin), or a placebo (inactive pill) daily for 26 weeks. Participants were already controlling their diabetes through a diet and exercise program, with some participants also taking metformin and/or insulin. Participants continued to take any previously prescribed treatments throughout the study.
After 26 weeks, participants who took Jardiance had an average A1C level (a measure of long-term blood glucose control) 0.84% lower than that of participants who took the placebo, a statistically significant difference — meaning a difference large enough that it could not be due to chance. Participants who took Tradjenta had an average A1C level 0.34% lower compared with placebo, which was not statistically significant.
“We know that people living with type 2 diabetes have a high risk for many diabetes complications, so it’s important to recognize and treat diabetes early in its course,” said study investigator Lori Laffel, MD, chief of the Pediatric, Adolescent, and Young Adult Section at the Joslin Diabetes Center and a professor of pediatrics at Harvard Medical School, in the press release. “These findings are particularly important given the need for more therapeutic options, especially oral agents, to manage type 2 diabetes in young people.”
Right now, the press release noted, metformin is the only oral drug approved for youth with type 2 diabetes that is available throughout the world. In some countries, this means that when diabetes treatment needs to be intensified, the only option available for young people is insulin — which is effective for lowering blood glucose, but carries potential side effects including weight gain and hypoglycemia (low blood glucose).
These study findings have been submitted for review in a medical journal, and may be the basis for a future application to have Jardiance approved for children and adolescents ages 10 to 17 with type 2 diabetes.
Want to learn more about type 2 diabetes? Read “Diabetes Testing: Type 2 Diabetes,” “Type 2 Diabetes and Obesity: The Link” and “Type 2 Diabetes and a Healthy Family Lifestyle.”
Quinn Phillips on social media
A freelance health writer and editor based in Wisconsin, Phillips has a degree from Harvard University. He is a former Editorial Assistant for Diabetes Self-Management and has years of experience covering diabetes and related health conditions. Phillips writes on a variety of topics, but is especially interested in the intersection of health and public policy.
Disclaimer of Medical Advice: Statements and opinions expressed on this Web site are those of the authors and not necessarily those of the publishers or advertisers. The information, which comes from qualified medical writers, does not constitute medical advice or recommendation of any kind, and you should not rely on any information contained in such posts or comments to replace consultations with your qualified health care professionals to meet your individual needs.
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