Deficiency of vitamin D could contribute to development of type 1 and type 2 diabetes: Study – News9 LIVE

2022-11-23T15:32:06+05:30
Vitamin D is an essential vitamin that is often linked to weak bones and poor muscles. The link between this crucial vitamin and serious illnesses like diabetes is one we often ignore.
However, exposure to sunlight helps the body to synthesize vitamin D, which is known as calciferol, and this is considered to be one of the most efficacious ways to supply the body with vitamin D, reports TOI.
There are many studies conducted on the association between vitamin D and diabetes.
Vitamin D improves the sensitivity of insulin which is crucial for maintaining blood glucose levels. It has to do with insulin secretion, insulin resistance, and β-cell dysfunction in the pancreas. In diabetic animal models, it has been seen that the secretion of pancreatic insulin is inhibited by vitamin D deficiency.
According to studies, the human body needs 80 nmol/l or more of vitamin D to maintain a normal glucose level. Research studies on older individuals have found that blood vitamin D levels of less than 50 nmol/l double the risk of diabetes.
As per a report published in Diabetes Spectrum, “There is growing evidence that vitamin D deficiency could be a contributing factor in the development of both type 1 and type 2 diabetes. First, the β-cell in the pancreas that secretes insulin has been shown to contain vitamin D receptors.”
“Vitamin D contributes to the normalisation of extracellular calcium, ensuring normal calcium flux through cell membranes; therefore, low vitamin D may diminish calcium’s ability to affect insulin secretion. Other potential mechanisms associated with vitamin D and diabetes include improving insulin action by stimulating expression of the insulin receptor, enhancing insulin responsiveness for glucose transport, having an indirect effect on insulin action potentially via a calcium effect on insulin secretion, and improving systemic inflammation by a direct effect on cytokines,” it adds.
However, there are some studies conducted on it but the outcome
Though several studies have worked on it majority of the results have been poorly understood.
The risk of diabetes was also lower in the vitamin D group than in the placebo group in a study conducted in Japan with 1256 adults with prediabetes to an active form of vitamin D analogue (eldecalcitol) or placebo, but the difference was once more not statistically significant.
A review article published in Nature says, “Vitamin D may play a role in type 2 diabetes; however, to better define the role of vitamin D in the development and progression of type 2 diabetes, high-quality observational studies and RCTs that measure blood 25-hydroxyvitamin D concentration and clinically relevant glycemic outcomes are needed.”
In patients with type 2 diabetes treated with metformin, a 2021 study published in Frontiers in Endocrinology found that the recommended doses of vitamin D significantly lowered the level of HbA1c after three and six months of vitamin D supplementation. It also noted that vitamin D may have beneficial effects only in vitamin D-deficient patients, particularly in those with poor glycemic control.
Along with diabetes, vitamin D is also associated with cardiovascular health. While there are studies which could not establish a constant link between vitamin D deficiency and heart health, deficiency of this essential vitamin increases blood pressure and causes other cardiovascular diseases.
However, there is no concrete conclusion on whether vitamin D supplements are the solution to a healthy heart.
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