Male Diabetics with infective endocarditis have lower in-hospital mortality compared to females – Medical Dialogues

A recent study found that Type 2 diabetic male patients had a higher incidence of infective endocarditis and lower rates of in-hospital mortality than women. The study was published in the journal Cardiovascular Diabetology.
Infective endocarditis is an infection with increased incidence in comorbid conditions like diabetes. Type 2 diabetics are at an increased risk of infection and show worse outcomes. But literature shows that the incidence and outcomes differ by sex. Hence researchers from Spain conducted a study to assess the sex differences in incidence, clinical characteristics, use of therapeutic procedures, and in-hospital outcomes in patients with infective endocarditis (IE) according to T2DM status from 2016 to 2020.
A retrospective cohort study was done using data from the Spanish National Hospital Discharge Database. The incidence of hospitalizations for IE in men and women aged ≥ 40 years with and without T2DM was estimated. Propensity score matching (PSM) and multivariable logistic regression were used to compare subgroups according to sex and the presence of T2DM.
Results
Thus, though T2DM was associated with an increased incidence of hospitalization for IE it was not associated with in-hospital mortality in IE in men or women. But T2 diabetics who had IE showed higher incidence and lower rates of in-hospital mortality in men.
Lopez-de-Andres, A., Jimenez-Garcia, R., Hernández-Barrera, V. et al. Sex-related disparities in the incidence and outcomes of infective endocarditis according to type 2 diabetes mellitus status in Spain, 2016–2020. Cardiovasc Diabetol 21, 198 (2022). https://doi.org/10.1186/s12933-022-01633-2
Dr.Niharika Harsha B (BDS,MDS) completed her BDS from Govt Dental College, Hyderabad and MDS from Dr.NTR University of health sciences(Now Kaloji Rao University). She has 4 years of private dental practice and worked for 2 years as Consultant Oral Radiologist at a Dental Imaging Centre in Hyderabad. She worked as Research Assistant and scientific writer in the development of Oral Anti cancer screening device with her seniors. She has a deep intriguing wish in writing highly engaging, captivating and informative medical content for a wider audience. She can be contacted at editorial@medicaldialogues.in.
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